| Players Picked at #5 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2026 | 5 | New York Giants | Arvell Reese | LB | Ohio State | |||||
| 2025 | 5 | Cleveland Browns | Mason Graham | DT | Michigan | |||||
| 2024 | 5 | Los Angeles Chargers | Joe Alt | T | Notre Dame | |||||
| 2023 | 5 | Seattle Seahawks | Devon Witherspoon | CB | Illinois | |||||
| 2022 | 5 | New York Giants | Kayvon Thibodeaux | DE | Oregon | |||||
| 2021 | 5 | Cincinnati Bengals | Ja'Marr Chase | WR | LSU | |||||
| 2020 | 5 | Miami Dolphins | Tua Tagovailoa | QB | Alabama | |||||
| 2019 | 5 | Tampa Bay Buccaneers | Devin White | ILB | LSU | |||||
| 2018 | 5 | Denver Broncos | Bradley Chubb | DE | North Carolina State | |||||
| 2017 | 5 | Tennessee Titans | Corey Davis | WR | Western Michigan | |||||
| 2016 | 5 | Jacksonville Jaguars | Jalen Ramsey | CB | Florida State | |||||
| 2015 | 5 | Washington Redskins | Brandon Scherff | T | Iowa | |||||
| 2014 | 5 | Oakland Raiders | Khalil Mack | LB | Buffalo | |||||
| 2013 | 5 | Detroit Lions | Ezekiel Ansah | DE | BYU | |||||
| 2012 | 5 | Jacksonville Jaguars | Justin Blackmon | WR | Oklahoma State | |||||
| 2011 | 5 | Arizona Cardinals | Patrick Peterson | CB | LSU | |||||
| 2010 | 5 | Kansas City Chiefs | Eric Berry | S | Tennessee | |||||
| 2009 | 5 | New York Jets | Mark Sanchez | QB | USC | |||||
| 2008 | 5 | Kansas City Chiefs | Glenn Dorsey | DT | LSU | |||||
| 2007 | 5 | Arizona Cardinals | Levi Brown | T | Penn State | |||||
| 2006 | 5 | Green Bay Packers | A.J. Hawk | ILB | Ohio State | |||||
| 2005 | 5 | Tampa Bay Buccaneers | Carnell Williams | RB | Auburn | |||||
| 2004 | 5 | Washington Redskins | Sean Taylor | S | Miami (FL) | |||||
| 2003 | 5 | Dallas Cowboys | Terrence Newman | CB | Kansas State | |||||
| 2002 | 5 | San Diego Chargers | Quentin Jammer | CB | Texas | |||||
| 2001 | 5 | San Diego Chargers | LaDainian Tomlinson | RB | TCU | HOF - 2017 | ||||
| 2000 | 5 | Baltimore Ravens | Jamal Lewis | RB | Tennessee | |||||
| 1999 | 5 | New Orleans Saints | Ricky Williams | RB | Texas | |||||
| 1998 | 5 | Chicago Bears | Curtis Enis | RB | Penn State | |||||
| 1997 | 5 | Detroit Lions | Bryant Westbrook | CB | Texas | |||||
| 1996 | 5 | New York Giants | Cedric Jones | DE | Oklahoma | |||||
| 1995 | 5 | Carolina Panthers | Kerry Collins | QB | Penn State | |||||
| 1994 | 5 | Indianapolis Colts | Trev Alberts | LB | Nebraska | |||||
| 1993 | 5 | Cincinnati Bengals | John Copeland | DE | Alabama | |||||
| 1992 | 5 | Green Bay Packers | Terrell Buckley | CB | Florida State | |||||
| 1991 | 5 | Los Angeles Rams | Todd Lyght | CB | Notre Dame | |||||
| 1990 | 5 | San Diego Chargers | Junior Seau | LB | USC | HOF - 2015 | ||||
| 1989 | 5 | Atlanta Falcons | Deion Sanders | CB | Florida State | HOF - 2011 | ||||
| 1988 | 5 | Cincinnati Bengals | Rickey Dixon | CB | Oklahoma | |||||
| 1987 | 5 | Cleveland Browns | Mike Junkin | ILB | Duke | |||||
| 1986 | 5 | St. Louis Cardinals | Anthony Bell | LB | Michigan State | |||||
| 1985 | 5 | Indianapolis Colts | Duane Bickett | OLB | USC | |||||
| 1984 | 5 | Kansas City Chiefs | Bill Maas | NT | Pittsburgh | |||||
| 1983 | 5 | San Diego Chargers | Billy Ray Smith | LB | Arkansas | |||||
| 1982 | 5 | Chicago Bears | Jim McMahon | QB | BYU | |||||
| 1981 | 5 | St. Louis Cardinals | E.J. Junior | LB | Alabama | |||||
| 1980 | 5 | Baltimore Colts | Curtis Dickey | RB | Texas A&M | |||||
| 1979 | 5 | Buffalo Bills | Jerry Butler | WR | Clemson | |||||
| 1978 | 5 | Buffalo Bills | Terry Miller | RB | Oklahoma State | |||||
| 1977 | 5 | New York Giants | Gary Jeter | DT | USC | |||||
| 1976 | 5 | New England Patriots | Mike Haynes | CB | Arizona State | HOF - 1997 | ||||
| 1975 | 5 | Cleveland Browns | Mack Mitchell | DE | Houston | |||||
| 1974 | 5 | Baltimore Colts | John Dutton | DE | Nebraska | |||||
| 1973 | 5 | St. Louis Cardinals | Dave Butz | DT | Purdue | |||||
| 1972 | 5 | Denver Broncos | Riley Odoms | TE | Houston | |||||
| 1971 | 5 | Philadelphia Eagles | Richard Harris | DE | Grambling State | |||||
| 1970 | 5 | Buffalo Bills | Al Cowlings | DE | USC | |||||
| 1969 | 5 | Cincinnati Bengals | Greg Cook | QB | Cincinnati | |||||
| 1968 | 5 | Green Bay Packers | Fred Carr | LB | Texas-El Paso | |||||
| 1967 | 5 | Houston Oilers | George Webster | LB | Michigan State | |||||
| 1966 | 5 | Dallas Cowboys | John Niland | G | Iowa | |||||
| 1965 | 5 | Dallas Cowboys | Craig Morton | QB | California | |||||
| 1964 | 5 | Detroit Lions | Pete Beathard | QB | USC | |||||
| 1963 | 5 | Baltimore Colts | Bob Vogel | T | Ohio State | |||||
| 1962 | 5 | Pittsburgh Steelers | Bob Ferguson | B | Ohio State | |||||
| 1961 | 5 | Chicago Bears | Mike Ditka | E | Pittsburgh | HOF - 1988 | ||||
| 1960 | 5 | Green Bay Packers | Tom Moore | HB | Vanderbilt | |||||
| 1959 | 5 | San Francisco 49ers | Dave Baker | QB | Oklahoma | |||||
| 1958 | 5 | Los Angeles Rams | Jim Phillips | WR | Auburn | |||||
| 1957 | 5 | Pittsburgh Steelers | Len Dawson | QB | Purdue | HOF - 1987 | ||||
| 1956 | 5 | Pittsburgh Steelers | Art Davis | HB | Mississippi State | |||||
| 1955 | 5 | Green Bay Packers | Tom Bettis | OLB | Purdue | |||||
| 1954 | 5 | Baltimore Colts | Cotton Davidson | QB | Baylor | |||||
| 1953 | 5 | Pittsburgh Steelers | Ted Marchibroda | QB | Detroit Mercy | |||||
| 1952 | 5 | Philadelphia Eagles | Johnny Bright | B | Drake | |||||
| 1951 | 5 | Green Bay Packers | Bob Gain | DE | Kentucky | |||||
| 1950 | 5 | Detroit Lions | Joe Watson | C | Rice | |||||
| 1949 | 5 | Green Bay Packers | Stan Heath | QB | Wisconsin | |||||
| 1948 | 5 | Boston Yanks | Vaughn Mancha | C | Alabama | |||||
| 1947 | 5 | Pittsburgh Steelers | Hub Bechtol | E | Texas | |||||
| 1946 | 5 | New York Giants | George Connor | T | Notre Dame | |||||
| 1945 | 5 | Cleveland Rams | Elroy Hirsch | WR | Michigan | HOF - 1968 | ||||
| 1944 | 5 | Philadelphia Eagles | Steve Van Buren | HB | LSU | HOF - 1965 | ||||
| 1943 | 5 | Cleveland Rams | Mike Holovak | FB | Boston College | |||||
| 1942 | 5 | Detroit Lions | Bob Westfall | FB | Michigan | |||||
| 1941 | 5 | Detroit Lions | Jim Thomason | HB | Texas A&M | |||||
| 1940 | 5 | Cleveland Rams | Olie Cordill | HB | Rice | |||||
| 1939 | 5 | Brooklyn Dodgers | Bob MacLeod | B | Dartmouth | |||||
| 1938 | 5 | Chicago Cardinals | Jack Robbins | B | Arkansas | |||||
| 1937 | 5 | Pittsburgh Pirates | Mike Basrak | C | Duquesne | |||||
| 1936 | 5 | Chicago Cardinals | Jim Lawrence | WB | TCU | |||||
NFL Draft - Overall Pick #5 Only