| Players Picked at #253 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2026 | 253 | Baltimore Ravens | Evan Beerntsen | G | Northwestern | |||||
| 2025 | 253 | Miami Dolphins | Zeek Biggers | DT | Georgia Tech | |||||
| 2024 | 253 | Los Angeles Chargers | Cornelius Johnson | WR | Michigan | |||||
| 2023 | 253 | San Francisco 49ers | Ronnie Bell | WR | Michigan | |||||
| 2022 | 253 | Los Angeles Rams | Russ Yeast | S | Kansas State | |||||
| 2021 | 253 | Denver Broncos | Marquiss Spencer | DE | Mississippi State | |||||
| 2020 | 253 | Minnesota Vikings | Kyle Hinton | C | Washburn | |||||
| 2019 | 253 | Washington Redskins | Jordan Brailford | DE | Oklahoma State | |||||
| 2018 | 253 | Cincinnati Bengals | Auden Tate | WR | Florida State | |||||
| 2017 | 253 | Denver Broncos | Chad Kelly | QB | Mississippi | |||||
| 2016 | 253 | Tennessee Titans | Kalan Reed | CB | Southern Mississippi | |||||
| 2015 | 253 | New England Patriots | Xzavier Dickson | OLB | Alabama | |||||
| 2014 | 253 | Atlanta Falcons | Yawin Smallwood | LB | Connecticut | |||||
| 2013 | 253 | New York Giants | Michael Cox | RB | Massachusetts | |||||
| 2012 | 253 | Indianapolis Colts | Chandler Harnish | QB | NIU | |||||
| 2011 | 253 | Washington Redskins | Chris Neild | DT | West Virginia | |||||
| 2010 | 253 | Tampa Bay Buccaneers | Erik Lorig | DE | Stanford | |||||
| 2009 | 253 | Jacksonville Jaguars | Tiquan Underwood | WR | Rutgers | |||||
| 2007 | 253 | Cincinnati Bengals | Chinedum Ndukwe | S | Notre Dame | |||||
| 2006 | 253 | Green Bay Packers | Dave Tollefson | DE | Northwest Missouri State | |||||
| 2005 | 253 | Tampa Bay Buccaneers | J.R. Russell | WR | Louisville | |||||
| 2004 | 253 | New York Giants | Isaac Hilton | DE | Hampton | |||||
| 2003 | 253 | Green Bay Packers | DeAndrew Rubin | WR | South Florida | |||||
| 2002 | 253 | New England Patriots | David Givens | WR | Notre Dame | |||||
| 2000 | 253 | Detroit Lions | Alfonso Boone | DT | Mt. San Antonio | |||||
| 1999 | 253 | Chicago Bears | Jim Finn | FB | Pennsylvania | |||||
| 1996 | 253 | Chicago Bears | Michael Hicks | RB | South Carolina State | |||||
| 1992 | 253 | Indianapolis Colts | Steve Grant | LB | West Virginia | |||||
| 1991 | 253 | Denver Broncos | Curtis Mayfield | WR | Oklahoma State | |||||
| 1990 | 253 | New England Patriots | Anthony Landry | RB | Stephen F. Austin | |||||
| 1989 | 253 | Detroit Lions | Jason Phillips | WR | Houston | |||||
| 1988 | 253 | Cincinnati Bengals | Ellis Dillahunt | DB | East Carolina | |||||
| 1987 | 253 | Indianapolis Colts | Chris Goode | DB | Alabama | |||||
| 1986 | 253 | New Orleans Saints | Jon Dumbauld | DE | Kentucky | |||||
| 1985 | 253 | Buffalo Bills | Chris Babyar | G | Illinois | |||||
| 1984 | 253 | Los Angeles Rams | Norwood Vann | TE | East Carolina | |||||
| 1983 | 253 | Green Bay Packers | Byron Williams | WR | Texas-Arlington | |||||
| 1982 | 253 | New England Patriots | Brian Clark | K | Florida | |||||
| 1981 | 253 | St. Louis Cardinals | James Mallard | WR | Alabama | |||||
| 1980 | 253 | Green Bay Packers | Jafus White | DB | Texas A&M-Kingsville | |||||
| 1979 | 253 | Buffalo Bills | Dave Marler | QB | Mississippi State | |||||
| 1978 | 253 | New York Giants | Greg Jorgensen | G | Nebraska | |||||
| 1977 | 253 | Pittsburgh Steelers | Alvin Cowans | DB | Florida | |||||
| 1976 | 253 | Detroit Lions | Leanell Jones | TE | Long Beach State | |||||
| 1975 | 253 | Buffalo Bills | Roland Hooks | RB | North Carolina State | |||||
| 1974 | 253 | Oakland Raiders | Chris Arnold | DB | Virginia State | |||||
| 1973 | 253 | San Francisco 49ers | Charlie Hunt | LB | Florida State | |||||
| 1972 | 253 | Cleveland Browns | Hershal Mosier | DT | NW Oklahoma State | |||||
| 1971 | 253 | Oakland Raiders | Tim Oesterling | DT | UCLA | |||||
| 1970 | 253 | Detroit Lions | Bruce Maxwell | RB | Arkansas | |||||
| 1969 | 253 | Minnesota Vikings | Tom McCauley | WR | Wisconsin | |||||
| 1968 | 253 | Miami Dolphins | Joe Mirto | T | Miami (FL) | |||||
| 1967 | 253 | Oakland Raiders | Richard Sligh | T | North Carolina College | |||||
| 1966 | 253 | Detroit Lions | Ralph Dunlap | DE | Baylor | |||||
| 1965 | 253 | New York Giants | Smith Reed | B | Alcorn State | |||||
| 1964 | 253 | San Francisco 49ers | Larry Rawson | B | Auburn | |||||
| 1963 | 253 | Los Angeles Rams | Dornel Nelson | B | Arizona State | |||||
| 1962 | 253 | Washington Redskins | Claude Crabb | B | Colorado | |||||
| 1961 | 253 | Minnesota Vikings | Bill Hill | RB | Presbyterian | |||||
| 1959 | 253 | Green Bay Packers | Charlie Anderson | E | Drake | |||||
| 1958 | 253 | Detroit Lions | Jim Wagstaff | B | Idaho State | |||||
| 1957 | 253 | New York Giants | Joe Smaltz | B | John Carroll | |||||
| 1956 | 253 | Cleveland Browns | Gene Kapish | E | Notre Dame | |||||
| 1955 | 253 | Cleveland Browns | Rick Spinks | B | Texas Tech | |||||
| 1954 | 253 | Detroit Lions | Jack Kistler | B | Duke | |||||
| 1953 | 253 | Detroit Lions | Bob Tata | B | Virginia | |||||
| 1952 | 253 | Los Angeles Rams | Art Preston | B | San Diego State | |||||
| 1951 | 253 | Chicago Bears | Larry Higgins | B | Fordham | |||||
| 1950 | 253 | Washington Redskins | George Bayer | T | Washington | |||||
| 1948 | 253 | Pittsburgh Steelers | Felton Whitlow | T | North Texas | |||||
| 1947 | 253 | Los Angeles Rams | Bob David | B | Villanova | |||||
| 1946 | 253 | Pittsburgh Steelers | Marchi Marino | T | Penn State | |||||
| 1945 | 253 | Chicago Cardinals | Hugo Norige | B | Wooster | |||||
| 1944 | 253 | Chicago Cardinals | John McGinnis | E | Notre Dame | |||||
| 1943 | 253 | Chicago Cardinals | Al Drulis | G | Temple | |||||