| Season | Date (Day) | Opponent | Location | Score | Result | W | L | T | |||||
| 1997 | Nov 9, 1997 (Sun) | @ Denver Broncos | Mile High Stadium | 0 - 34 | Loss | 0 | 1 | 0 | stats | ||||
| 2004 | Oct 10, 2004 (Sun) | @ Denver Broncos | Invesco Field at Mile High | 17 - 20 | Loss | 0 | 2 | 0 | stats | ||||
| 2008 | Dec 14, 2008 (Sun) | Denver Broncos | Bank of America Stadium | 30 - 10 | Win | 1 | 2 | 0 | stats | ||||
| 2012 | Nov 11, 2012 (Sun) | Denver Broncos | Bank of America Stadium | 14 - 36 | Loss | 1 | 3 | 0 | stats | ||||
| 2015 | Feb 7, 2016 (Sun) | @ Denver Broncos | Playoff | Levi's Stadium | 10 - 24 | Loss | 1 | 4 | 0 | stats | |||
| 2016 | Sep 8, 2016 (Thu) | @ Denver Broncos | Sports Authority Field at Mile High | 20 - 21 | Loss | 1 | 5 | 0 | stats | ||||
| 2020 | Dec 13, 2020 (Sun) | Denver Broncos | Bank of America Stadium | 27 - 32 | Loss | 1 | 6 | 0 | stats | ||||
| 2022 | Nov 27, 2022 (Sun) | Denver Broncos | Bank of America Stadium | 23 - 10 | Win | 2 | 6 | 0 | stats | ||||
| 2024 | Oct 27, 2024 (Sun) | @ Denver Broncos | Empower Field at Mile High | 14 - 28 | Loss | 2 | 7 | 0 | stats |
Panthers vs. Broncos History