| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 5, 2025 (Fri) | Kansas City Chiefs | Corinthians Arena | 27 - 21 | Win | 1-0-0 | 1-0-0 | stats | standings | ||
| 2 | Sep 15, 2025 (Mon) | @ Las Vegas Raiders | Allegiant Stadium | 20 - 9 | Win | 2-0-0 | 2-0-0 | stats | standings | ||
| 3 | Sep 21, 2025 (Sun) | Denver Broncos | SoFi Stadium | 23 - 20 | Win | 3-0-0 | 3-0-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | @ New York Giants | MetLife Stadium | 18 - 21 | Loss | 3-1-0 | 3-1-0 | stats | standings | ||
| 5 | Oct 5, 2025 (Sun) | Washington Commanders | SoFi Stadium | 10 - 27 | Loss | 3-2-0 | 3-2-0 | stats | standings | ||
| 6 | Oct 12, 2025 (Sun) | @ Miami Dolphins | Hard Rock Stadium | 29 - 27 | Win | 4-2-0 | 4-2-0 | stats | standings | ||
| 7 | Oct 19, 2025 (Sun) | Indianapolis Colts | SoFi Stadium | 24 - 38 | Loss | 4-3-0 | 4-3-0 | stats | standings | ||
| 8 | Oct 23, 2025 (Thu) | Minnesota Vikings | SoFi Stadium | 37 - 10 | Win | 5-3-0 | 5-3-0 | stats | standings | ||
| 9 | Nov 2, 2025 (Sun) | @ Tennessee Titans | Nissan Stadium | 27 - 20 | Win | 6-3-0 | 6-3-0 | stats | standings | ||
| 10 | Nov 9, 2025 (Sun) | Pittsburgh Steelers | SoFi Stadium | 25 - 10 | Win | 7-3-0 | 7-3-0 | stats | standings | ||
| 11 | Nov 16, 2025 (Sun) | @ Jacksonville Jaguars | TIAA Bank Field | 6 - 35 | Loss | 7-4-0 | 7-4-0 | stats | standings | ||
| 13 | Nov 30, 2025 (Sun) | Las Vegas Raiders | SoFi Stadium | 4:25 PM EST | |||||||
| 14 | Dec 8, 2025 (Mon) | Philadelphia Eagles | SoFi Stadium | 8:15 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | @ Kansas City Chiefs | GEHA Field at Arrowhead Stadium | 1:00 PM EST | |||||||
| 16 | Dec 21, 2025 (Sun) | @ Dallas Cowboys | AT&T Stadium | 1:00 PM EST | |||||||
| 17 | Dec 29, 2025 (Mon) | Houston Texans | SoFi Stadium | 1:00 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | @ Denver Broncos | Empower Field at Mile High | 1:00 PM EST | |||||||
Los Angeles Chargers Schedule - 2025