| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 7, 2025 (Sun) | Carolina Panthers | TIAA Bank Field | 26 - 10 | Win | 1-0-0 | 1-0-0 | stats | standings | ||
| 2 | Sep 14, 2025 (Sun) | @ Cincinnati Bengals | Paycor Stadium | 27 - 31 | Loss | 1-1-0 | 1-1-0 | stats | standings | ||
| 3 | Sep 21, 2025 (Sun) | Houston Texans | TIAA Bank Field | 17 - 10 | Win | 2-1-0 | 2-1-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | @ San Francisco 49ers | Levi's Stadium | 26 - 21 | Win | 3-1-0 | 3-1-0 | stats | standings | ||
| 5 | Oct 6, 2025 (Mon) | Kansas City Chiefs | TIAA Bank Field | 31 - 28 | Win | 4-1-0 | 4-1-0 | stats | standings | ||
| 6 | Oct 12, 2025 (Sun) | Seattle Seahawks | TIAA Bank Field | 12 - 20 | Loss | 4-2-0 | 4-2-0 | stats | standings | ||
| 7 | Oct 19, 2025 (Sun) | Los Angeles Rams | Wembley Stadium | 7 - 35 | Loss | 4-3-0 | 4-3-0 | stats | standings | ||
| 9 | Nov 2, 2025 (Sun) | @ Las Vegas Raiders | Allegiant Stadium | 30 - 29 | Win | OT | 5-3-0 | 5-3-0 | stats | standings | |
| 10 | Nov 9, 2025 (Sun) | @ Houston Texans | NRG Stadium | 29 - 36 | Loss | 5-4-0 | 5-4-0 | stats | standings | ||
| 11 | Nov 16, 2025 (Sun) | Los Angeles Chargers | TIAA Bank Field | 35 - 6 | Win | 6-4-0 | 6-4-0 | stats | standings | ||
| 12 | Nov 23, 2025 (Sun) | @ Arizona Cardinals | State Farm Stadium | 4:05 PM EST | |||||||
| 13 | Nov 30, 2025 (Sun) | @ Tennessee Titans | Nissan Stadium | 1:00 PM EST | |||||||
| 14 | Dec 7, 2025 (Sun) | Indianapolis Colts | TIAA Bank Field | 1:00 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | New York Jets | TIAA Bank Field | 1:00 PM EST | |||||||
| 16 | Dec 21, 2025 (Sun) | @ Denver Broncos | Empower Field at Mile High | 4:05 PM EST | |||||||
| 17 | Dec 28, 2025 (Sun) | @ Indianapolis Colts | Lucas Oil Stadium | 1:00 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | Tennessee Titans | TIAA Bank Field | 1:00 PM EST | |||||||
Jacksonville Jaguars Schedule - 2025