| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 7, 2025 (Sun) | Miami Dolphins | Lucas Oil Stadium | 33 - 8 | Win | 1-0-0 | 1-0-0 | stats | standings | ||
| 2 | Sep 14, 2025 (Sun) | Denver Broncos | Lucas Oil Stadium | 29 - 28 | Win | 2-0-0 | 2-0-0 | stats | standings | ||
| 3 | Sep 21, 2025 (Sun) | @ Tennessee Titans | Nissan Stadium | 41 - 20 | Win | 3-0-0 | 3-0-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | @ Los Angeles Rams | SoFi Stadium | 20 - 27 | Loss | 3-1-0 | 3-1-0 | stats | standings | ||
| 5 | Oct 5, 2025 (Sun) | Las Vegas Raiders | Lucas Oil Stadium | 40 - 6 | Win | 4-1-0 | 4-1-0 | stats | standings | ||
| 6 | Oct 12, 2025 (Sun) | Arizona Cardinals | Lucas Oil Stadium | 31 - 27 | Win | 5-1-0 | 5-1-0 | stats | standings | ||
| 7 | Oct 19, 2025 (Sun) | @ Los Angeles Chargers | SoFi Stadium | 38 - 24 | Win | 6-1-0 | 6-1-0 | stats | standings | ||
| 8 | Oct 26, 2025 (Sun) | Tennessee Titans | Lucas Oil Stadium | 38 - 14 | Win | 7-1-0 | 7-1-0 | stats | standings | ||
| 9 | Nov 2, 2025 (Sun) | @ Pittsburgh Steelers | Acrisure Stadium | 20 - 27 | Loss | 7-2-0 | 7-2-0 | stats | standings | ||
| 10 | Nov 9, 2025 (Sun) | Atlanta Falcons | Olympiastadion | 31 - 25 | Win | OT | 8-2-0 | 8-2-0 | stats | standings | |
| 12 | Nov 23, 2025 (Sun) | @ Kansas City Chiefs | GEHA Field at Arrowhead Stadium | 1:00 PM EST | |||||||
| 13 | Nov 30, 2025 (Sun) | Houston Texans | Lucas Oil Stadium | 1:00 PM EST | |||||||
| 14 | Dec 7, 2025 (Sun) | @ Jacksonville Jaguars | TIAA Bank Field | 1:00 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | @ Seattle Seahawks | Lumen Field | 4:25 PM EST | |||||||
| 16 | Dec 22, 2025 (Mon) | San Francisco 49ers | Lucas Oil Stadium | 8:15 PM EST | |||||||
| 17 | Dec 28, 2025 (Sun) | Jacksonville Jaguars | Lucas Oil Stadium | 1:00 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | @ Houston Texans | NRG Stadium | 1:00 PM EST | |||||||
Indianapolis Colts Schedule - 2025