| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 7, 2025 (Sun) | @ Los Angeles Rams | SoFi Stadium | 9 - 14 | Loss | 0-1-0 | 0-1-0 | stats | standings | ||
| 2 | Sep 15, 2025 (Mon) | Tampa Bay Buccaneers | NRG Stadium | 19 - 20 | Loss | 0-2-0 | 0-2-0 | stats | standings | ||
| 3 | Sep 21, 2025 (Sun) | @ Jacksonville Jaguars | TIAA Bank Field | 10 - 17 | Loss | 0-3-0 | 0-3-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | Tennessee Titans | NRG Stadium | 26 - 0 | Win | 1-3-0 | 1-3-0 | stats | standings | ||
| 5 | Oct 5, 2025 (Sun) | @ Baltimore Ravens | M&T Bank Stadium | 44 - 10 | Win | 2-3-0 | 2-3-0 | stats | standings | ||
| 7 | Oct 20, 2025 (Mon) | @ Seattle Seahawks | Lumen Field | 19 - 27 | Loss | 2-4-0 | 2-4-0 | stats | standings | ||
| 8 | Oct 26, 2025 (Sun) | San Francisco 49ers | NRG Stadium | 26 - 15 | Win | 3-4-0 | 3-4-0 | stats | standings | ||
| 9 | Nov 2, 2025 (Sun) | Denver Broncos | NRG Stadium | 15 - 18 | Loss | 3-5-0 | 3-5-0 | stats | standings | ||
| 10 | Nov 9, 2025 (Sun) | Jacksonville Jaguars | NRG Stadium | 36 - 29 | Win | 4-5-0 | 4-5-0 | stats | standings | ||
| 11 | Nov 16, 2025 (Sun) | @ Tennessee Titans | Nissan Stadium | 16 - 13 | Win | 5-5-0 | 5-5-0 | stats | standings | ||
| 12 | Nov 20, 2025 (Thu) | Buffalo Bills | NRG Stadium | 8:15 PM EST | |||||||
| 13 | Nov 30, 2025 (Sun) | @ Indianapolis Colts | Lucas Oil Stadium | 1:00 PM EST | |||||||
| 14 | Dec 7, 2025 (Sun) | @ Kansas City Chiefs | GEHA Field at Arrowhead Stadium | 8:20 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | Arizona Cardinals | NRG Stadium | 1:00 PM EST | |||||||
| 16 | Dec 21, 2025 (Sun) | Las Vegas Raiders | NRG Stadium | 4:25 PM EST | |||||||
| 17 | Dec 29, 2025 (Mon) | @ Los Angeles Chargers | SoFi Stadium | 1:00 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | Indianapolis Colts | NRG Stadium | 1:00 PM EST | |||||||
Houston Texans Schedule - 2025