| Season | Date (Day) | Opponent | Location | Score | Result | W | L | T | |||||
| 1970 | Nov 22, 1970 (Sun) | @ Chicago Bears | Wrigley Field | 13 - 31 | Loss | 0 | 1 | 0 | |||||
| 1974 | Oct 27, 1974 (Sun) | Chicago Bears | Rich Stadium | 16 - 6 | Win | 1 | 1 | 0 | |||||
| 1979 | Oct 7, 1979 (Sun) | Chicago Bears | Rich Stadium | 0 - 7 | Loss | 1 | 2 | 0 | |||||
| 1988 | Oct 2, 1988 (Sun) | @ Chicago Bears | Soldier Field | 3 - 24 | Loss | 1 | 3 | 0 | |||||
| 1991 | Sep 29, 1991 (Sun) | Chicago Bears | Rich Stadium | 35 - 20 | Win | 2 | 3 | 0 | |||||
| 1994 | Oct 2, 1994 (Sun) | @ Chicago Bears | Soldier Field | 13 - 20 | Loss | 2 | 4 | 0 | |||||
| 1997 | Dec 7, 1997 (Sun) | @ Chicago Bears | Soldier Field | 3 - 20 | Loss | 2 | 5 | 0 | |||||
| 2000 | Nov 12, 2000 (Sun) | Chicago Bears | Ralph Wilson Stadium | 20 - 3 | Win | 3 | 5 | 0 | stats | ||||
| 2002 | Sep 29, 2002 (Sun) | Chicago Bears | Ralph Wilson Stadium | 33 - 27 | Win | OT | 4 | 5 | 0 | stats | |||
| 2006 | Oct 8, 2006 (Sun) | @ Chicago Bears | Soldier Field | 7 - 40 | Loss | 4 | 6 | 0 | stats | ||||
| 2010 | Nov 7, 2010 (Sun) | Chicago Bears | Rogers Centre | 19 - 22 | Loss | 4 | 7 | 0 | stats | ||||
| 2014 | Sep 7, 2014 (Sun) | @ Chicago Bears | Soldier Field | 23 - 20 | Win | OT | 5 | 7 | 0 | stats | |||
| 2018 | Nov 4, 2018 (Sun) | Chicago Bears | New Era Field | 9 - 41 | Loss | 5 | 8 | 0 | stats | ||||
| 2022 | Dec 24, 2022 (Sat) | @ Chicago Bears | Soldier Field | 35 - 13 | Win | 6 | 8 | 0 | stats |
Bills vs. Bears History