| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 7, 2025 (Sun) | @ Green Bay Packers | Lambeau Field | 13 - 27 | Loss | 0-1-0 | 0-1-0 | stats | standings | ||
| 2 | Sep 14, 2025 (Sun) | Chicago Bears | Ford Field | 52 - 21 | Win | 1-1-0 | 1-1-0 | stats | standings | ||
| 3 | Sep 22, 2025 (Mon) | @ Baltimore Ravens | M&T Bank Stadium | 38 - 30 | Win | 2-1-0 | 2-1-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | Cleveland Browns | Ford Field | 1:00 PM EDT | |||||||
| 5 | Oct 5, 2025 (Sun) | @ Cincinnati Bengals | Paycor Stadium | 4:25 PM EDT | |||||||
| 6 | Oct 12, 2025 (Sun) | @ Kansas City Chiefs | GEHA Field at Arrowhead Stadium | 8:20 PM EDT | |||||||
| 7 | Oct 20, 2025 (Mon) | Tampa Bay Buccaneers | Ford Field | 7:00 PM EDT | |||||||
| 9 | Nov 2, 2025 (Sun) | Minnesota Vikings | Ford Field | 1:00 PM EST | |||||||
| 10 | Nov 9, 2025 (Sun) | @ Washington Commanders | Commanders Field | 4:25 PM EST | |||||||
| 11 | Nov 16, 2025 (Sun) | @ Philadelphia Eagles | Lincoln Financial Field | 8:20 PM EST | |||||||
| 12 | Nov 23, 2025 (Sun) | New York Giants | Ford Field | 1:00 PM EST | |||||||
| 13 | Nov 27, 2025 (Thu) | Green Bay Packers | Ford Field | 1:00 PM EST | |||||||
| 14 | Dec 4, 2025 (Thu) | Dallas Cowboys | Ford Field | 8:15 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | @ Los Angeles Rams | SoFi Stadium | 4:25 PM EST | |||||||
| 16 | Dec 21, 2025 (Sun) | Pittsburgh Steelers | Ford Field | 4:25 PM EST | |||||||
| 17 | Dec 25, 2025 (Thu) | @ Minnesota Vikings | U.S. Bank Stadium | 4:30 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | @ Chicago Bears | Soldier Field | 1:00 PM EST | |||||||
Detroit Lions Schedule - 2025