| Regular Season | By Quarter Scores | |||||||||||
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 7, 2025 (Sun) | Arizona Cardinals | Caesars Superdome | 13 - 20 | Loss | 0-1-0 | 0-1-0 | stats | standings | ||
| 2 | Sep 14, 2025 (Sun) | San Francisco 49ers | Caesars Superdome | 21 - 26 | Loss | 0-2-0 | 0-2-0 | stats | standings | ||
| 3 | Sep 21, 2025 (Sun) | @ Seattle Seahawks | Lumen Field | 13 - 44 | Loss | 0-3-0 | 0-3-0 | stats | standings | ||
| 4 | Sep 28, 2025 (Sun) | @ Buffalo Bills | Highmark Stadium | 19 - 31 | Loss | 0-4-0 | 0-4-0 | stats | standings | ||
| 5 | Oct 5, 2025 (Sun) | New York Giants | Caesars Superdome | 26 - 14 | Win | 1-4-0 | 1-4-0 | stats | standings | ||
| 6 | Oct 12, 2025 (Sun) | New England Patriots | Caesars Superdome | 19 - 25 | Loss | 1-5-0 | 1-5-0 | stats | standings | ||
| 7 | Oct 19, 2025 (Sun) | @ Chicago Bears | Soldier Field | 14 - 23 | Loss | 1-6-0 | 1-6-0 | stats | standings | ||
| 8 | Oct 26, 2025 (Sun) | Tampa Bay Buccaneers | Caesars Superdome | 3 - 23 | Loss | 1-7-0 | 1-7-0 | stats | standings | ||
| 9 | Nov 2, 2025 (Sun) | @ Los Angeles Rams | SoFi Stadium | 10 - 34 | Loss | 1-8-0 | 1-8-0 | stats | standings | ||
| 10 | Nov 9, 2025 (Sun) | @ Carolina Panthers | Bank of America Stadium | 17 - 7 | Win | 2-8-0 | 2-8-0 | stats | standings | ||
| 12 | Nov 23, 2025 (Sun) | Atlanta Falcons | Caesars Superdome | 4:25 PM EST | |||||||
| 13 | Nov 30, 2025 (Sun) | @ Miami Dolphins | Hard Rock Stadium | 1:00 PM EST | |||||||
| 14 | Dec 7, 2025 (Sun) | @ Tampa Bay Buccaneers | Raymond James Stadium | 1:00 PM EST | |||||||
| 15 | Dec 14, 2025 (Sun) | Carolina Panthers | Caesars Superdome | 4:25 PM EST | |||||||
| 16 | Dec 21, 2025 (Sun) | New York Jets | Caesars Superdome | 1:00 PM EST | |||||||
| 17 | Dec 28, 2025 (Sun) | @ Tennessee Titans | Nissan Stadium | 1:00 PM EST | |||||||
| 18 | Jan 4, 2026 (Sun) | @ Atlanta Falcons | Mercedes-Benz Stadium | 1:00 PM EST | |||||||
New Orleans Saints Schedule - 2025